5'-Modified oligonucleotides

5'-Amino-C6

• Primary amino group attached to a 6-carbon spacer
• Useful for the attachment of fluorescent reporter groups, biotin, digoxigenin, and enzymes or antibodies
• Used for immobilization of oligonucleotides on solid supports

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product	scale	amount	cat. no.	price/coupling
5'-Amino-C6	0.05 µmol	5 nmol	5-0210-112	28.00 EUR
	0.20 µmol	25 nmol	5-0210-113	38.00 EUR
	1.00 µmol	100 nmol	5-0210-114	58.00 EUR

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5'-Amino-C12

• Primary amino group attached to a 12-carbon spacer
• Greater spacing between oligonucleotide and reporter groups
• Can reduce intramolecular quenching of fluorescence
• Useful for affinity chromatography

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product	scale	amount	cat. no.	price/coupling
5'-Amino-C12	0.05 µmol	5 nmol	5-0210-212	48.50 EUR
	0.20 µmol	25 nmol	5-0210-213	64.00 EUR
	1.00 µmol	100 nmol	5-0210-214	79.00 EUR

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5'-Branching (5'-Branch)

• Each coupling doubles the amount of sites used for coupling with modifications

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product	scale	amount	cat. no.	price/coupling
5'-Branch	0.05 µmol	5 nmol	5-0210-222	64.00 EUR
	0.20 µmol	25 nmol	5-0210-223	95.00 EUR
	1.00 µmol	100 nmol	5-0210-224	130.00 EUR

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5'-Carboxyl Group

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product	scale	amount	cat. no.	price/coupling
5'-Carboxyl	0.05 µmol	5 nmol	5-0210-232	64.00 EUR
	0.20 µmol	25 nmol	5-0210-233	79.00 EUR
	1.00 µmol	100 nmol	5-0210-234	115.00 EUR

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5'-Cholesteryl (5'-Chol)

• Useful in antisense technology
• The highly lipophilic compound facilitates membrane penetration

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product	scale	amount	cat. no.	price/coupling
5'-Chol	0.05 µmol	5 nmol	5-0210-312	99.00 EUR
	0.20 µmol	25 nmol	5-0210-313	145.00 EUR
	1.00 µmol	100 nmol	5-0210-314	195.00 EUR

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5'-Hexaethylenglycol (5'-HEGL)

• Hydrophilic spacer
• Can also be introduced at internal sites
• In hammerhead ribozymes it can replace the tetra-loop of stem II with essentially no decrease in activity compared with the wild-type ribozyme

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product	scale	amount	cat. no.	price/coupling
5'-HEGL	0.05 µmol	5 nmol	5-0210-412	38.00 EUR
	0.20 µmol	25 nmol	5-0210-413	48.00 EUR
	1.00 µmol	100 nmol	5-0210-414	99.00 EUR

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5'-Phosphate (5'-Phos)

• For ligation of PCR products
• Very high degree of phosphorylation (>95%)
• Superior to enzymatic methods

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product	scale	amount	cat. no.	price/coupling
5'-Phos	0.05 µmol	5 nmol	5-0210-512	28.00 EUR
	0.20 µmol	25 nmol	5-0210-513	38.00 EUR
	1.00 µmol	100 nmol	5-0210-514	68.00 EUR

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5'-Psoralen-C2 (5'-PsorC2)

• For cross-linking double-stranded oligonucleotides

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product	scale	amount	cat. no.	price/coupling
5'-PsorC2	0.05 µmol	5 nmol	5-0210-612	99.00 EUR
	0.20 µmol	25 nmol	5-0210-613	115.00 EUR
	1.00 µmol	100 nmol	5-0210-614	166.00 EUR

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5'-Psoralen-C6 (5'-PsorC6)

• For cross-linking triple helices

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product	scale	amount	cat. no.	price/coupling
5'-PsorC6	0.05 µmol	5 nmol	5-0210-712	99.00 EUR
	0.20 µmol	25 nmol	5-0210-713	115.00 EUR
	1.00 µmol	100 nmol	5-0210-714	166.00 EUR

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5'-Thiol-C6 (5'-SH)

• For coupling oligonucleotides with maleimide or iodoacetate activated antibodies, peptides, enzymes or fluorescent dyes
• Useful for double labelings with different dyes (5'-thiol in combination with internal- or 3'-amino-groups)

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product	scale	amount	cat. no.	price/coupling
5'-SH	0.05 µmol	5 nmol	5-0210-812	38.00 EUR
	0.20 µmol	25 nmol	5-0210-813	48.00 EUR
	1.00 µmol	100 nmol	5-0210-814	79.00 EUR

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5'-Triethylenglycol (5'-TriGl)

• Hydrophilic spacer
• Can also be coupled at internal sites

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product	scale	amount	cat. no.	price/coupling
5'-TriGl	0.05 µmol	5 nmol	5-0210-912	38.00 EUR
	0.20 µmol	25 nmol	5-0210-913	48.50 EUR
	1.00 µmol	100 nmol	5-0210-914	99.00 EUR

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