Oligonucleotides with internal modifications

Cytidine modifications

2',3'-Dideoxycytidine (2',3'-ddC)
5-Methyl-2'-deoxycytidine (5-Me-2'-dC)
5-Bromo-2'-deoxycytidine (5-Br-2'-dC)
5-Iodo-2'-deoxycytidine (5-I-2'-dC)
N4-Methyl-deoxycytidine (N4-Methyl dC)
3'-Deoxycytidine (3'-dC)

2',3'-Dideoxycytidine (2',3'-ddC)

• Useful for blocking the extension of oligonucleotides e.g. during PCR
• No substrate for RNA- and DNA-ligases

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product	scale	amount	cat. no.	price/coupling
2' 3'-ddC	0.05 µmol	5 nmol	5-0231-012	64.00 EUR
	0.20 µmol	25 nmol	5-0231-013	95.00 EUR
	1.00 µmol	100 nmol	5-0231-014	130.00 EUR

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5-Methyl-2'-deoxycytidine (5-Me-2'-dC)

• Increases melting temperature by 1.3°C per 5-Methyl-2'-dC/dG base pair

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product	scale	amount	cat. no.	price/coupling
5-Me-2'-dC	0.05 µmol	5 nmol	5-0231-112	55.00 EUR
	0.20 µmol	25 nmol	5-0231-113	79.00 EUR
	1.00 µmol	100 nmol	5-0231-114	95.00 EUR

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5-Bromo-2'-deoxycytidine (5-Br-2'-dC)

• Halogenated nucleosides are useful for crystallography
• Useful for probing the structure of Protein-RNA, Protein-DNA and DNA-RNA complexes in crosslinking experiments

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product	scale	amount	cat. no.	price/coupling
5-Br-2'-dC	0.05 µmol	5 nmol	5-0231-212	55.00 EUR
	0.20 µmol	25 nmol	5-0231-213	79.00 EUR
	1.00 µmol	100 nmol	5-0231-214	95.00 EUR

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5-Iodo-2'-deoxycytidine (5-I-2'-dC)

• Halogenated nucleosides are useful for crystallography
• Useful for probing the structure of Protein-RNA, Protein-DNA and RNA-RNA complexes in crosslinking experiments

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product	scale	amount	cat. no.	price/coupling
5-I-2'-dC	0.05 µmol	5 nmol	5-0231-312	55.00 EUR
	0.20 µmol	25 nmol	5-0231-313	79.00 EUR
	1.00 µmol	100 nmol	5-0231-314	95.00 EUR

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N4-Methyl-deoxycytidine (N4-Methyl dC)

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product	scale	amount	cat. no.	price/coupling
N4-Methyl dC	0.05 µmol	5 nmol	5-0231-412	79.00 EUR
	0.20 µmol	25 nmol	5-0231-413	95.00 EUR
	1.00 µmol	100 nmol	5-0231-414	115.00 EUR

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3'-Deoxycytidine (3'-dC)

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product	scale	amount	cat. no.	price/coupling
3'-dC	0.05 µmol	5 nmol	5-0231-512	99.00 EUR
	0.20 µmol	25 nmol	5-0231-513	115.00 EUR
	1.00 µmol	100 nmol	5-0231-514	165.00 EUR

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