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Streptamers - a break-through in T-cell research |
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Summary
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| Reversible, antigen-specific T-cell staining |
The Streptamer technology is a novel method to isolate and characterize functional antigen-specific T-cells. Streptamers enable for the first time a reversible, antigen-specific staining of T-cells, leaving the isolated T-cells phenotypically and functionally indistinguishable from untreated cells. Streptamer-isolated T-cells may offer new strategies for treating uncurable diseases including viral infections and cancer by adoptive T-cell transfer. In addition, the technology is likely to advance basic T-cell research as an essential prerequisite for novel immunological medicines. A recent publication by Dirk H. Busch (et al.), the inventor of the Streptamer technology, was featured in the June 2002 issue of Nature Medicine. It introduced the Streptamer technology as a method to isolate, for the first time, fully functional antigen-specific T-cells. Experiments in mice demonstrate that the Streptamer technology is capable to provide antigen-specific T-cells, which efficiently can be applied in adoptive transfer protocols. Reference: Knabel M et. al., 2002, Nature Medicine 6: 631-637.  |
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