Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Locked nucleic acid-modified antisense oligonucleotides (ASOs) can obtain strongly totally different levels of goal knockdown regardless of having comparable biophysical properties and 100% homology with their goal. The determinants for this statement stay largely unknown. We used multi-specific ASOs which have 100% sequence complementarity with a typical goal (IDO1) and a special variety of numerous […]