Advanced oligonucleotide (oligo) libraries are important supplies for various functions in artificial biology, pharmaceutical manufacturing, nanotechnology and DNA-based knowledge storage. Nonetheless, the error charges in synthesizing complicated oligo libraries will be substantial, resulting in increment in price and labor for the functions. As most synthesis errors come up from defective insertions and deletions, we developed […]
Category: Gerbil
Efficient synthesis of 2′-O-methoxyethyl oligonucleotide – cationic peptide conjugates
Single-stranded phosphorothioate (PS) oligonucleotide medication have proven potential for the remedy of a number of uncommon illnesses. Nevertheless, a barrier to their widespread use is that they exhibit exercise in solely a slender vary of tissues. One technique to circumvent this constraint is to conjugate them to cationic cell-penetrating peptides (CPPs). Though there are a […]