Oligonucleotides fluorescence in situ hybridization (Oligo-FISH) is an rising know-how and is a crucial device in analysis areas comparable to detection of chromosome variation, identification of allopolyploid, and deciphering of three-dimensional (3D) genome constructions. Primarily based on the demand for extremely environment friendly oligo probes for oligo-FISH experiments, growing numbers of instruments have been developed for probe design lately. Out of date oligonucleotide design instruments have been tailored for oligo-FISH probe design due to their comparable issues.
With the event of DNA sequencing and large-scale synthesis, novel instruments have been designed to extend the specificity of designed oligo probes and allow genome-scale oligo probe design, which has tremendously improved the appliance of single copy oligo-FISH. Regardless of this, few research have launched the event of the oligo-FISH probe design instruments and their utility in FISH experiments systematically. Apart from, a complete comparability and analysis is missing for the out there instruments. On this evaluation, we offer an outline of the oligo-FISH probe design course of, summarize the event and utility of the out there instruments, consider a number of state-of-art instruments, and finally present steering for single copy oligo-FISH probe design.
At the moment there’s an pressing must develop antiviral medicine and alleviate present COVID-19 pandemic. Though many candidates have been developed, we right here designed and constructed chimeric oligonucleotides comprising a 2′-OMe modified antisense oligonucleotide and a 5′-phosphorylated 2′-5′ poly(A) 4 (4A 2-5 ) to degrade envelope and spike RNAs of SARS-CoV-2. The oligonucleotide was used for looking and recognizing goal viral RNA sequence, and the conjugated 4A 2-5 was used for guided ribonuclease L (RNase L) activation to sequence-specifically degrade viral RNAs.
Since RNase L can potently cleave single strand RNA throughout innate antiviral response, degradation efficiencies with these chimeras have been twice as a lot as solely 2′-OMe modified oligonucleotides for each SARS-CoV-2 RNA targets. In pseudovirus an infection fashions, one of many chimeras concentrating on spike RNA achieved potent and broad-spectrum inhibition of SARS-CoV-2 and its N501Y and/or ΔH69/ΔV70 mutants.
Simultaneous quantitation of inorganic ions in oligonucleotides utilizing mixed-mode liquid chromatography coupled with a charged aerosol detector
The quantities of inorganic ions (e.g. sodium, potassium, magnesium, calcium, chloride, and phosphate) in intrathecally administered oligonucleotide drug merchandise should be managed with a view to meet the ultimate goal formulation composition. Throughout course of growth, these ions are measured to make sure the answer composition doesn’t change throughout purification or drug product compounding and to make sure the ultimate drug product targets are achieved.
A quantitative methodology for ion evaluation in antisense oligonucleotide (ASO) medicine was developed by mixed-mode anion trade/cation exchange-hydrophilic interplay liquid chromatography (AEX/CEX-HILIC) with a charged aerosol detector (CAD). This thirteen-minute methodology measures monovalent and multivalent cations and anions concurrently. LC separation circumstances, CAD parameters, and pattern preparation have been judiciously optimized to make sure that the strategy is restricted, correct, exact, linear, strong, and rugged. With this LC-CAD method, ion evaluation for oligonucleotide medicine may be carried out in most analytical labs to help drug growth.
Antisense Oligonucleotide-Mediated Discount of HDAC6 Does Not Scale back Tau Pathology in P301S Tau Transgenic Mice
Acetylation of tau protein is dysregulated in Alzheimer’s Illness (AD). It has been proposed that acetylation of particular websites within the KXGS motif of tau can regulate phosphorylation of close by residues and scale back the propensity of tau to mixture. Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme concerned in deacetylation of a number of targets, together with tau, and it has been steered that inhibition of HDAC6 would enhance tau acetylation on the KXGS motifs and thus might current a viable therapeutic method to deal with AD.
To instantly take a look at the contribution of HDAC6 to tau pathology, we intracerebroventricularly injected an antisense oligonucleotide (ASO) directed towards HDAC6 mRNA into brains of P301S tau mice (PS19 mannequin), which resulted in a 70% knockdown of HDAC6 protein within the mind. Regardless of a sturdy lower in ranges of HDAC6, no enhance in tau acetylation was noticed. Moreover, no change of tau phosphorylation or tau aggregation was detected upon the knockdown of HDAC6. We conclude that HDAC6 doesn’t affect tau pathology in PS19 mice.
Efficient silencing of miR-126 after ischemic stroke via intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice
Mind endothelial cells (BECs) are concerned within the pathogenesis of ischemic stroke. Lately, a number of microRNAs (miRNAs) in BECs have been reported to manage the endothelial operate in ischemic mind. Due to this fact, modulation of miRNAs in BECs by a therapeutic oligonucleotide to inhibit miRNA (antimiR) might be a helpful technique for treating ischemic stroke. Nevertheless, few makes an attempt have been made to realize this technique through systemic route because of lack of environment friendly delivery-method towards BECs.
Right here, we have now developed a brand new know-how for delivering an antimiR into BECs and silencing miRNAs in BECs, utilizing a mouse ischemic stroke mannequin. We designed a heteroduplex oligonucleotide, comprising an antimiR towards miRNA-126 (miR-126) often called the endothelial-specific miRNA and its complementary RNA, conjugated to α-tocopherol as a supply ligand (Toc-HDO concentrating on miR-126). Intravenous administration of Toc-HDO concentrating on miR-126 remarkably suppressed miR-126 expression in ischemic mind of the mannequin mice.
Human Protein FAM129B (FAM129B) ELISA Kit |
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| abx387257-96tests | Abbexa | 96 tests | EUR 1093.2 |
FAM129B siRNA |
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| 20-abx901842 | Abbexa |
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FAM129B siRNA |
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| 20-abx916030 | Abbexa |
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FAM129B siRNA |
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| 20-abx916031 | Abbexa |
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FAM129B (Ab-712) Antibody |
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| CSB-PA998601-100ul | Cusabio | 100ul | EUR 379.2 |
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Description: A polyclonal antibody against FAM129B (Ab-712). Recognizes FAM129B (Ab-712) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200 |
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FAM129B (Ab-712) Antibody |
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| CSB-PA998601- | Cusabio | each | EUR 402 |
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Description: A polyclonal antibody against FAM129B (Ab-712). Recognizes FAM129B (Ab-712) from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200 |
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FAM129B Antibody / MINERVA / NIBAN2 |
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| RQ6569 | NSJ Bioreagents | 100ug | EUR 419 |
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Description: FAM129B/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A/Niban and FAM129C/Niban-like protein 2. FAM129A/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma. FAM129C/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma. FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells. Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines. Deletion of FAM129B in melanoma cells significantly impairs B-Raf/MEK/Erk-dependent invasion into the extracellular matrix. |
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pCMV-SPORT6-FAM129B |
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| PVT12950 | Lifescience Market | 2 ug | EUR 469.2 |
Rabbit Anti-Human FAM129B (aa 710-714) Polyclonal Antibody |
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| CPB-1199RH | Creative Diagnostics | 100 ul | EUR 552 |
Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 336 |
Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 336 |
Human FAM129B shRNA Plasmid |
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| 20-abx962121 | Abbexa |
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Mouse FAM129B shRNA Plasmid |
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| 20-abx981593 | Abbexa |
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Rat FAM129B shRNA Plasmid |
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| 20-abx990325 | Abbexa |
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FAM129B ELISA KIT|Human |
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| EF009517 | Lifescience Market | 96 Tests | EUR 826.8 |
FAM129B Recombinant Protein (Rat) |
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| RP200402 | ABM | 100 ug | Ask for price |
FAM129B Recombinant Protein (Human) |
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| RP057474 | ABM | 100 ug | Ask for price |
FAM129B Recombinant Protein (Mouse) |
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| RP132935 | ABM | 100 ug | Ask for price |
Fam129b ORF Vector (Rat) (pORF) |
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| ORF066802 | ABM | 1.0 ug DNA | EUR 607.2 |
FAM129B ORF Vector (Human) (pORF) |
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| ORF019159 | ABM | 1.0 ug DNA | EUR 486 |
Fam129b ORF Vector (Mouse) (pORF) |
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| ORF044313 | ABM | 1.0 ug DNA | EUR 607.2 |
FAM129B sgRNA CRISPR Lentivector set (Human) |
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| K0745701 | ABM | 3 x 1.0 ug | EUR 406.8 |
Fam129b sgRNA CRISPR Lentivector set (Mouse) |
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| K4870701 | ABM | 3 x 1.0 ug | EUR 406.8 |
Fam129b sgRNA CRISPR Lentivector set (Rat) |
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| K6504001 | ABM | 3 x 1.0 ug | EUR 406.8 |
Family with Sequence Similarity 129, Member B (FAM129B) Antibody |
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| abx331409-100ul | Abbexa | 100 ul | EUR 510 |
Family With Sequence Similarity 129, Member B (FAM129B) Antibody |
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| abx232965-100ug | Abbexa | 100 ug | EUR 610.8 |
FAM129B sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K0745702 | ABM | 1.0 ug DNA | EUR 184.8 |
FAM129B sgRNA CRISPR Lentivector (Human) (Target 2) |
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| K0745703 | ABM | 1.0 ug DNA | EUR 184.8 |
FAM129B sgRNA CRISPR Lentivector (Human) (Target 3) |
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| K0745704 | ABM | 1.0 ug DNA | EUR 184.8 |
Fam129b sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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| K4870702 | ABM | 1.0 ug DNA | EUR 184.8 |
Fam129b sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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| K4870703 | ABM | 1.0 ug DNA | EUR 184.8 |
Fam129b sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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| K4870704 | ABM | 1.0 ug DNA | EUR 184.8 |
Fam129b sgRNA CRISPR Lentivector (Rat) (Target 1) |
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| K6504002 | ABM | 1.0 ug DNA | EUR 184.8 |
Fam129b sgRNA CRISPR Lentivector (Rat) (Target 2) |
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| K6504003 | ABM | 1.0 ug DNA | EUR 184.8 |
Fam129b sgRNA CRISPR Lentivector (Rat) (Target 3) |
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| K6504004 | ABM | 1.0 ug DNA | EUR 184.8 |
FAM129B Protein Vector (Human) (pPB-C-His) |
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| PV076633 | ABM | 500 ng | EUR 662.4 |
FAM129B Protein Vector (Human) (pPB-N-His) |
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| PV076634 | ABM | 500 ng | EUR 662.4 |
FAM129B Protein Vector (Human) (pPM-C-HA) |
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| PV076635 | ABM | 500 ng | EUR 662.4 |
FAM129B Protein Vector (Human) (pPM-C-His) |
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| PV076636 | ABM | 500 ng | EUR 662.4 |
FAM129B Protein Vector (Mouse) (pPB-C-His) |
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| PV177250 | ABM | 500 ng | EUR 1278 |
FAM129B Protein Vector (Mouse) (pPB-N-His) |
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| PV177251 | ABM | 500 ng | EUR 1278 |
FAM129B Protein Vector (Mouse) (pPM-C-HA) |
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| PV177252 | ABM | 500 ng | EUR 1278 |
FAM129B Protein Vector (Mouse) (pPM-C-His) |
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| PV177253 | ABM | 500 ng | EUR 1278 |
FAM129B 3'UTR Luciferase Stable Cell Line |
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| TU007555 | ABM | 1.0 ml | EUR 1825.2 |
Fam129b 3'UTR GFP Stable Cell Line |
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| TU254268 | ABM | 1.0 ml | Ask for price |
Fam129b 3'UTR Luciferase Stable Cell Line |
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| TU106140 | ABM | 1.0 ml | Ask for price |
FAM129B 3'UTR GFP Stable Cell Line |
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| TU057555 | ABM | 1.0 ml | EUR 1825.2 |
Fam129b 3'UTR Luciferase Stable Cell Line |
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| TU204268 | ABM | 1.0 ml | Ask for price |
Fam129b 3'UTR GFP Stable Cell Line |
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| TU156140 | ABM | 1.0 ml | Ask for price |
FAM129B Protein Vector (Rat) (pPB-C-His) |
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| PV267206 | ABM | 500 ng | EUR 1399.2 |
FAM129B Protein Vector (Rat) (pPB-N-His) |
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| PV267207 | ABM | 500 ng | EUR 1399.2 |
FAM129B Protein Vector (Rat) (pPM-C-HA) |
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| PV267208 | ABM | 500 ng | EUR 1399.2 |
FAM129B Protein Vector (Rat) (pPM-C-His) |
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| PV267209 | ABM | 500 ng | EUR 1399.2 |
Mouse Niban- like protein 1, Fam129b ELISA KIT |
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| ELI-35343m | Lifescience Market | 96 Tests | EUR 1038 |
FAM129B Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
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| LV667033 | ABM | 1.0 ug DNA | EUR 1626 |
FAM129B Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
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| LV667037 | ABM | 1.0 ug DNA | EUR 1626 |
FAM129B Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
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| LV667038 | ABM | 1.0 ug DNA | EUR 1626 |
Human Niban- like protein 1, FAM129B ELISA KIT |
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| ELI-13124h | Lifescience Market | 96 Tests | EUR 988.8 |
FAM129B sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
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| K0745705 | ABM | 3 x 1.0 ug | EUR 451.2 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
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| K4870705 | ABM | 3 x 1.0 ug | EUR 451.2 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
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| K6504005 | ABM | 3 x 1.0 ug | EUR 451.2 |
FAM129B Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
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| LV667034 | ABM | 1.0 ug DNA | EUR 1626 |
FAM129B Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
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| LV667035 | ABM | 1.0 ug DNA | EUR 1695.6 |
FAM129B Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
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| LV667036 | ABM | 1.0 ug DNA | EUR 1695.6 |
FAM129B sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
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| K0745706 | ABM | 1.0 ug DNA | EUR 200.4 |
FAM129B sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
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| K0745707 | ABM | 1.0 ug DNA | EUR 200.4 |
FAM129B sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
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| K0745708 | ABM | 1.0 ug DNA | EUR 200.4 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
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| K4870706 | ABM | 1.0 ug DNA | EUR 200.4 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
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| K4870707 | ABM | 1.0 ug DNA | EUR 200.4 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
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| K4870708 | ABM | 1.0 ug DNA | EUR 200.4 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
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| K6504006 | ABM | 1.0 ug DNA | EUR 200.4 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
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| K6504007 | ABM | 1.0 ug DNA | EUR 200.4 |
Fam129b sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
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| K6504008 | ABM | 1.0 ug DNA | EUR 200.4 |
Anti-Anti-SEPT6 antibody antibody |
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| STJ11100949 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. |
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Anti-Anti-SEPT9 Antibody antibody |
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| STJ111369 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. |
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Anti-Anti-SEPT11 Antibody antibody |
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| STJ111530 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT4 Antibody antibody |
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| STJ112276 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. |
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Anti-Anti-MARCH9 Antibody antibody |
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| STJ112609 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT11 Antibody antibody |
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| STJ113941 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT11 Antibody antibody |
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| STJ114081 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT5 Antibody antibody |
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| STJ114819 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
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Anti-Anti-MARCH8 Antibody antibody |
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| STJ114828 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT7 Antibody antibody |
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| STJ116214 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
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Anti-Anti-SEPT8 Antibody antibody |
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| STJ117206 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Anti-Anti-SEPT12 Antibody antibody |
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| STJ117759 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Anti-Anti-MARCH6 Antibody antibody |
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| STJ118549 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-MARCH6 Antibody antibody |
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| STJ118550 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-MARCH7 Antibody antibody |
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| STJ118752 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT3 Antibody antibody |
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| STJ118990 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT2 Antibody antibody |
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| STJ28365 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT7 Antibody antibody |
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| STJ28963 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
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Anti-Anti-SEPT2 Antibody antibody |
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| STJ25475 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Anti-SEPT5 Antibody antibody |
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| STJ25477 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
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Anti-Anti-SEPT8 Antibody antibody |
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| STJ25479 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Anti-Anti-SEPT1 antibody antibody |
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| STJ119580 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012] |
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Anti-Anti-DDB1 Antibody |
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| A00333 | BosterBio | 100uL | EUR 546 |
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Description: Rabbit Polyclonal DDB1 Antibody. Validated in IP and tested in Human, Mouse. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 6777.36 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 663.31 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 896.16 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| AEA465Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3672.72 |
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Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
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Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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| 4-AEA465Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
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ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody) |
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| ELK8071 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
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Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Anti-ZNF660 antibody |
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| 44742-100ul | SAB | 100ul | EUR 302.4 |
Anti-ZNF660 antibody |
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| 44742-50ul | SAB | 50ul | EUR 224.4 |
Anti-CCV Antibody |
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| 10-2789 | Fitzgerald | 1 mg | EUR 217.2 |
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Description: Anti-Canine Corona Virus Antibody |
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Anti-CCV Antibody |
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| 10-2790 | Fitzgerald | 1 mg | EUR 217.2 |
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Description: Anti-Canine Corona Virus Antibody |
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Anti-CDV antibody |
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| 10-2791 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Canine Distemper Virus antibody |
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Anti-CDV antibody |
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| 10-2792 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Canine Distemper Virus antibody |
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Anti-CDV antibody |
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| 10-2793 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Canine Distemper Virus antibody |
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Anti-CDV antibody |
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| 10-2794 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Canine Distemper Virus antibody |
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Anti-CPV Antibody |
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| 10-2795 | Fitzgerald | 500 uig | EUR 165.6 |
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Description: Anti-Canine Parvo Virus Antibody |
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Anti-CPV Antibody |
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| 10-2796 | Fitzgerald | 500 ug | EUR 165.6 |
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Description: Anti-Canine Parvo Virus Antibody |
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Anti-CPV Antibody |
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| 10-2797 | Fitzgerald | 500 ug | EUR 165.6 |
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Description: Anti-Canine Parvo Virus Antibody |
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Anti-C.CRP antibody |
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| 10-2798 | Fitzgerald | 500 ug | EUR 165.6 |
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Description: Anti-Canine CRP antibody |
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Anti-C.CRP antibody |
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| 10-2799 | Fitzgerald | 500 ug | EUR 165.6 |
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Description: Anti-Canine CRP antibody |
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Anti-CHW antibody |
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| 10-2800 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Canine Heartworm antibody |
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Anti-FeLV antibody |
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| 10-2801 | Fitzgerald | 1 mg | EUR 217.2 |
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Description: Anti-Feline Leukemia Virus antibody |
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Anti-FeLV antibody |
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| 10-2802 | Fitzgerald | 1 mg | EUR 217.2 |
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Description: Anti-Feline Leukemia Virus antibody |
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Anti-FeLV antibody |
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| 10-2803 | Fitzgerald | 1 mg | EUR 217.2 |
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Description: Anti-Feline Leukemia Virus antibody |
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Anti-PGI antibody |
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| 10-2806 | Fitzgerald | 1 mg | EUR 502.8 |
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Description: Anti-PGI recombinant antibody |
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Anti-PGI antibody |
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| 10-2807 | Fitzgerald | 1 mg | EUR 502.8 |
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Description: Anti-PGI recombinant antibody |
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Anti-PGII antibody |
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| 10-2808 | Fitzgerald | 1 mg | EUR 502.8 |
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Description: Anti-PGII recombinant antibody |
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Anti-PGII antibody |
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| 10-2809 | Fitzgerald | 1 mg | EUR 502.8 |
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Description: Anti-PGII recombinant antibody |
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Anti-CHW antibody |
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| 10-2810 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-CHW monoclonal antibody |
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Anti-Giardia antibody |
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| 10-2811 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Giardia monoclonal antibody |
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Anti-Giardia antibody |
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| 10-2812 | Fitzgerald | 1 mg | EUR 198 |
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Description: Anti-Giardia monoclonal antibody |
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Anti-TAP1 Antibody |
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| A01123 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal TAP1 Antibody. Validated in IP, IHC, WB and tested in Human, Rat. |
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Anti-CHD4 Antibody |
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| A01125 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal CHD4 Antibody. Validated in IF, IHC and tested in Human, Mouse. |
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Anti-NRF1 Antibody |
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| A01129-2 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-MEF2C Antibody |
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| A01131-1 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-SCN4A Antibody |
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| A01138 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal SCN4A Antibody. Validated in WB and tested in Human. |
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Anti-MTR Antibody |
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| A01140-2 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-IL12B Antibody |
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| A01152-2 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-IL12B Antibody |
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| A01152-3 | BosterBio | 100ug/vial | EUR 400.8 |
Anti-IL12B Antibody |
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| A01152-4 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-IL11 Antibody |
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| A01160-1 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-Bak Antibody |
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| A01163 | BosterBio | 200ug | EUR 626.4 |
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Description: Rabbit Polyclonal Bak Antibody. Validated in IP, IF, IHC, WB and tested in Human. |
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Anti-PGF Antibody |
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| A01164-1 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-PGF Antibody |
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| A01164-2 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-CD201 Antibody |
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| A01166 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Antibody for CD201 Antibody (PROCR) detection.tested for IHC, WB in Human, Mouse, Rat. |
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Anti-SERCA2 Antibody |
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| A01176 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Antibody for SERCA2 Antibody (ATP2A2) detection.tested for IHC, WB in Human, Mouse, Rat. |
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Anti-XPA Antibody |
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| A01182 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal XPA Antibody. Validated in IHC, WB and tested in Human. |
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Anti-XPA Antibody |
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| A01182-1 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Antibody for XPA Antibody (XPA) detection.tested for WB in Human, Mouse. |
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As well as, we confirmed that Toc-HDO concentrating on miR-126 was delivered into BECs extra effectively than the guardian antimiR in ischemic mind, and that it was delivered extra successfully in ischemic mind than non-ischemic mind of this mannequin mice. Our research highlights the potential of this know-how as a brand new medical therapeutic possibility for ischemic stroke.