Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Locked nucleic acid-modified antisense oligonucleotides (ASOs) can obtain strongly totally different levels of goal knockdown regardless of having comparable biophysical properties and 100% homology with their goal. The determinants for this statement stay largely unknown. We used multi-specific ASOs which have 100% sequence complementarity with a typical goal (IDO1) and a special variety of numerous targets and investigated their impact on gene expression in a cell line by RNA-sequencing. We noticed a major larger likelihood for downregulation of lengthy genes in comparison with brief genes, of genes with excessive in comparison with decrease expression, and of genes which have a couple of binding web site for the respective ASO.

By investigating the expression of genes which have binding websites for a couple of ASO we recognized the person binding web site being an vital determinant for exercise. Underneath the chosen experimental circumstances we have now not seen indications that availability of RNase H is a limiting issue because the variety of degraded goal RNA molecules correlated considerably with the variety of predicted goal RNA molecules. Taken collectively, through the use of multi-specific ASOs as software compounds we recognized determinants for ASO exercise that may be considered to enhance the choice technique of extremely potent and selective ASOs sooner or later.

Liver-Focused Supply of Oligonucleotides with N-Acetylgalactosamine Conjugation

The potential therapeutic utility of oligonucleotides (ONs) that selectively suppress goal genes by means of antisense and RNA interference mechanisms has attracted nice consideration. The medical functions of ONs have overcome a number of obstacles and turn into one of the crucial energetic areas for the event of novel therapeutics. To attain environment friendly and particular mobile internalization, conjugation of a wide range of purposeful teams to ONs has been the topic of intensive investigations over the previous decade. Amongst them, a promising liver-targeted N-acetylgalactosamine (GalNAc) ligand has been evaluated in a number of preclinical and medical trials for enhancing the mobile uptake and tissue particular supply of ONs.

GalNAc-based supply depends on the truth that liver hepatocytes abundantly and particularly categorical the asialoglycoprotein receptor that binds and uptakes circulating glycoproteins by way of receptor-mediated endocytosis. Lately, encouraging progress has been made within the discipline of GalNAc conjugates. This assessment goals to supply an summary of GalNAc-mediated liver-targeted supply of small interfering RNA and antisense oligonucleotides, and the immense effort in addition to current advances within the improvement of GalNAc-conjugated brokers are described.

Molecular analysis of viral genotyping devoid of polymerase chain response (PCR) amplification in medical cohorts has hitherto been difficult. Right here we current a simplified molecular diagnostic technique for direct genotyping of hepatitis C virus (HCV) 1 and three (prevalent worldwide) utilizing a mix of rationally designed genotype-specific antisense oligonucleotides (ASOs) and plasmonic gold nanoparticles. The ASOs particular to genotypes 1 and three have been designed from the nonstructural area 5A (NS5A) of the viral genome utilizing the ClustalW a number of sequence alignment software.

A complete of 79 medical samples together with 18 HCV genotype 1, 18 HCV genotype 3, one HIV constructive, one HBV constructive, and 41 wholesome controls have been examined towards each the designed ASOs. The research reveals 100% specificity and sensitivity with the employed samples and thereby opens up new avenues for PCR-free direct genotyping of different viruses as nicely, by means of the rational design of ASOs.

Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

A extremely potent lead ASO, effectively delivered by free uptake, was capable of considerably enhance the extent of accurately spliced mRNA and fully restore the CFTR operate to wild kind ranges in cells from a homozygote affected person. This ASO led to CFTR operate with a median of 43% of untamed kind ranges in cells from varied heterozygote sufferers. Optimized effectivity of the lead ASO was additional obtained with 2′-Methoxy Ethyl modification (2’MOE). The extremely environment friendly splicing modulation and purposeful correction, achieved by free uptake of the chosen lead ASO in varied sufferers, exhibit the ASO therapeutic potential profit for CF sufferers carrying splicing mutations and is aimed to function the premise for our present medical improvement.

PaintSHOP allows the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments

Fluorescence in situ hybridization (FISH) permits researchers to visualise the spatial place and amount of nucleic acids in mounted samples. Not too long ago, appreciable progress has been made in growing oligonucleotide (oligo)-based FISH strategies which have enabled researchers to review the three-dimensional group of the genome at super-resolution and visualize the spatial patterns of gene expression for 1000’s of genes in particular person cells. Nevertheless, there are few present computational instruments to assist the bioinformatics workflows obligatory to hold out these experiments utilizing oligo FISH probes.

Right here, we introduce paint server and homology optimization pipeline (PaintSHOP), an interactive platform for the design of oligo FISH experiments. PaintSHOP allows researchers to establish probes for his or her experimental targets effectively, to include extra obligatory sequences equivalent to primer pairs and to simply generate recordsdata documenting library design. PaintSHOP democratizes and standardizes the method of designing complicated probe units for the oligo FISH neighborhood.

HIBADH Antibody

DF12632-200ul 200ul
EUR 350

HIBADH Antibody

E91264 100ul
EUR 255
Description: Available in various conjugation types.

HIBADH antibody

70R-17734 50 ul
EUR 289
Description: Rabbit polyclonal HIBADH antibody

HIBADH antibody

70R-2475 50 ug
EUR 467
Description: Rabbit polyclonal HIBADH antibody raised against the middle region of HIBADH

HIBADH antibody

70R-2529 50 ug
EUR 467
Description: Rabbit polyclonal HIBADH antibody raised against the middle region of HIBADH

HIBADH antibody

70R-33913 100 ug
EUR 294
Description: Rabbit polyclonal HIBADH antibody

HIBADH Antibody

1-CSB-PA010346GA01HU
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  • Ask for price
  • 150ul
  • 50ul
Description: A polyclonal antibody against HIBADH. Recognizes HIBADH from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

HIBADH Antibody

1-CSB-PA006776
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against HIBADH. Recognizes HIBADH from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

HIBADH Antibody

1-CSB-PA566343
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  • 100ul
  • 50ul
Description: A polyclonal antibody against HIBADH. Recognizes HIBADH from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

HIBADH Antibody

ABD13117 100ug
EUR 325

HIBADH Antibody

GWB-MS913D 50ug Ask for price

HIBADH Antibody

GWB-MS914E 50ug Ask for price

HIBADH Antibody

MBS7126902-005mL 0.05mL
EUR 190

HIBADH Antibody

MBS7126902-01mL 0.1mL
EUR 270

HIBADH Antibody

MBS7126902-5x01mL 5x0.1mL
EUR 1205

HIBADH Antibody

MBS7118913-005mg 0.05mg
EUR 150

HIBADH Antibody

MBS7118913-01mg 0.1mg
EUR 190

HIBADH Antibody

MBS7118913-5x01mg 5x0.1mg
EUR 845

HIBADH Antibody

MBS9401267-005mL 0.05mL
EUR 245

HIBADH Antibody

MBS9401267-01mL 0.1mL
EUR 305

HIBADH Antibody

MBS9401267-5x01mL 5x0.1mL
EUR 1230

HIBADH Antibody

MBS8502613-01mL 0.1mL
EUR 325

HIBADH Antibody

MBS8502613-01mLAF405L 0.1mL(AF405L)
EUR 565

HIBADH Antibody

MBS8502613-01mLAF405S 0.1mL(AF405S)
EUR 565

HIBADH Antibody

MBS8502613-01mLAF610 0.1mL(AF610)
EUR 565

HIBADH Antibody

MBS8502613-01mLAF635 0.1mL(AF635)
EUR 565

HIBADH Antibody

MBS852512-01mg 0.1mg
EUR 305

HIBADH Antibody

MBS852512-01mLAF405L 0.1mL(AF405L)
EUR 465

HIBADH Antibody

MBS852512-01mLAF405S 0.1mL(AF405S)
EUR 465

HIBADH Antibody

MBS852512-01mLAF610 0.1mL(AF610)
EUR 465

HIBADH Antibody

MBS852512-01mLAF635 0.1mL(AF635)
EUR 465

HIBADH Antibody

MBS9611384-01mL 0.1mL
EUR 260

HIBADH Antibody

MBS9611384-02mL 0.2mL
EUR 305

HIBADH Antibody

MBS9611384-5x02mL 5x0.2mL
EUR 1220

HIBADH Antibody

MBS9505913-005mL 0.05mL
EUR 285

HIBADH Antibody

MBS9505913-01mL 0.1mL
EUR 385

HIBADH Antibody

MBS9505913-5x01mL 5x0.1mL
EUR 1590

HIBADH Antibody

C14092-100ul 100μl
EUR 217
Description: HIBADH Rabbit Polyclonal Antibody

HIBADH Antibody

C14092-50ul 50μl
EUR 143.5
Description: HIBADH Rabbit Polyclonal Antibody

anti- HIBADH antibody

FNab03855 100µg
EUR 658.5
Description: Antibody raised against HIBADH

HIBADH Antibody (N-term)

MBS9202601-008mL 0.08mL
EUR 210

HIBADH Antibody (N-term)

MBS9202601-04mL 0.4mL
EUR 430

HIBADH Antibody (N-term)

MBS9202601-5x04mL 5x0.4mL
EUR 1910

HIBADH antibody - middle region

MBS3211133-01mL 0.1mL
EUR 455

HIBADH antibody - middle region

MBS3211133-5x01mL 5x0.1mL
EUR 1995

HIBADH antibody - middle region

MBS3211134-01mL 0.1mL
EUR 455

HIBADH antibody - middle region

MBS3211134-5x01mL 5x0.1mL
EUR 1995

OAAF03138-100UG - HIBADH Antibody

OAAF03138-100UG 100ug
EUR 329

HIBADH Polyclonal Antibody

ABP53601-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of HIBADH from Human, Mouse, Rat. This HIBADH antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human HIBADH at AA rangle: 250-330

HIBADH Polyclonal Antibody

ABP53601-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of HIBADH from Human, Mouse, Rat. This HIBADH antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human HIBADH at AA rangle: 250-330

HIBADH Polyclonal Antibody

ABP53601-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of HIBADH from Human, Mouse, Rat. This HIBADH antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human HIBADH at AA rangle: 250-330

HIBADH Polyclonal Antibody

E20-72131 100ug
EUR 225
Description: Available in various conjugation types.

HIBADH Conjugated Antibody

C34327 100ul
EUR 476.4

HIBADH Polyclonal Antibody

E-AB-92346-120uL 120uL
EUR 320
Description: Unconjugated

HIBADH Polyclonal Antibody

E-AB-92346-200uL 200uL
EUR 530
Description: Unconjugated

HIBADH Polyclonal Antibody

E-AB-92346-60uL 60uL
EUR 200
Description: Unconjugated

HIBADH Polyclonal Antibody

E-AB-92346-each each Ask for price
Description: Unconjugated

HIBADH Polyclonal Antibody

A73425 50 μl
EUR 557

HIBADH Polyclonal Antibody

BT-AP03961-100ul 100ul Ask for price
Description: HIBADH encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The 3-hydroxyisobutyrate dehydrogenase plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

HIBADH Polyclonal Antibody

BT-AP03961-20ul 20ul Ask for price
Description: HIBADH encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The 3-hydroxyisobutyrate dehydrogenase plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

HIBADH Polyclonal Antibody

BT-AP03961-50ul 50ul Ask for price
Description: HIBADH encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The 3-hydroxyisobutyrate dehydrogenase plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

HIBADH Polyclonal Antibody

E44H04982 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HIBADH Polyclonal Antibody

MBS8523112-01mg 0.1mg
EUR 305

HIBADH Polyclonal Antibody

MBS8523112-01mLAF405L 0.1mL(AF405L)
EUR 465

HIBADH Polyclonal Antibody

MBS8523112-01mLAF405S 0.1mL(AF405S)
EUR 465

HIBADH Polyclonal Antibody

MBS8523112-01mLAF610 0.1mL(AF610)
EUR 465

HIBADH Polyclonal Antibody

MBS8523112-01mLAF635 0.1mL(AF635)
EUR 465

HIBADH Polyclonal Antibody

MBS2516432-002mL 0.02mL
EUR 140

HIBADH Polyclonal Antibody

MBS2516432-006mL 0.06mL
EUR 180

HIBADH Polyclonal Antibody

MBS2516432-012mL 0.12mL
EUR 260

HIBADH Polyclonal Antibody

MBS2516432-02mL 0.2mL
EUR 405

HIBADH Polyclonal Antibody

MBS2554664-006mL 0.06mL
EUR 190

HIBADH Polyclonal Antibody

MBS2554664-012mL 0.12mL
EUR 265

HIBADH Polyclonal Antibody

MBS2554664-02mL 0.2mL
EUR 415

HIBADH Polyclonal Antibody

MBS2554664-5x02mL 5x0.2mL
EUR 1835

HIBADH Conjugated Antibody

MBS9445135-01mLAF350 0.1mL(AF350)
EUR 480

HIBADH Conjugated Antibody

MBS9445135-01mLAF405 0.1mL(AF405)
EUR 480

HIBADH Conjugated Antibody

MBS9445135-01mLAF488 0.1mL(AF488)
EUR 480

HIBADH Conjugated Antibody

MBS9445135-01mLAF555 0.1mL(AF555)
EUR 480

HIBADH Conjugated Antibody

MBS9445135-01mLBiotin 0.1mL(Biotin)
EUR 480

HIBADH Polyclonal Antibody

RD81051A-120uL 120μL
EUR 360
Description: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

HIBADH Polyclonal Antibody

RD81051A-200uL 200μL
EUR 630
Description: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

HIBADH Polyclonal Antibody

RD81051A-60uL 60μL
EUR 204
Description: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

Polyclonal HIBADH Antibody (N-term)

APR07742G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIBADH (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal HIBADH Antibody (aa281-330)

APR07741G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIBADH (aa281-330). This antibody is tested and proven to work in the following applications:

HIBADH Antibody (N-term) Blocking Peptide

MBS9222924-INQUIRE INQUIRE Ask for price

HIBADH Rabbit Polyclonal Antibody

53406 100ul
EUR 439

HIBADH Rabbit Polyclonal Antibody

ES4600-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against HIBADH from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

HIBADH Rabbit Polyclonal Antibody

ES4600-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against HIBADH from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

HIBADH Rabbit Polyclonal Antibody

E10G10714 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HIBADH Rabbit Polyclonal Antibody

MBS9464668-005mL 0.05mL
EUR 300

HIBADH Rabbit Polyclonal Antibody

MBS9464668-01mL 0.1mL
EUR 390

HIBADH Rabbit Polyclonal Antibody

MBS9464668-5x01mL 5x0.1mL
EUR 1610

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx110711
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx121493
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  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx029841-400ul 400 ul
EUR 627.6

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx029841-80l 80 µl
EUR 343.2

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx014090
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx001170
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx233855-100ug 100 ug
EUR 610.8

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx214624
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx326435
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx110711-100l 100 µl
EUR 612.5

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx029841-400l 400 µl
EUR 518.75

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx214624-100g 100 µg
EUR 350

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx214624-25g 25 µg
EUR 250

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx233855-100g 100 µg
EUR 350

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx326435-100g 100 µg
EUR 250

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx326435-50g 50 µg
EUR 187.5

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx375104-96tests 96 tests
EUR 337.5

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx014090-100l 100 µl
EUR 43.75

ARP53111_P050-25UL - HIBADH Antibody - middle region

ARP53111_P050-25UL 25ul
EUR 99

ARP53112_P050-25UL - HIBADH Antibody - middle region

ARP53112_P050-25UL 25ul
EUR 99

ARP53111_P050 - HIBADH antibody - middle region (ARP53111_P050)

ARP53111_P050 100ul
EUR 389

ARP53112_P050 - HIBADH antibody - middle region (ARP53112_P050)

ARP53112_P050 100ul
EUR 389

HIBADH

E8ER1910-59 100ul
EUR 275
Description: Available in various conjugation types.

HIBADH

MBS8577749-01mL 0.1mL
EUR 345

HIBADH

MBS8577749-01mLAF405L 0.1mL(AF405L)
EUR 565

HIBADH

MBS8577749-01mLAF405S 0.1mL(AF405S)
EUR 565

HIBADH

MBS8577749-01mLAF610 0.1mL(AF610)
EUR 565

HIBADH

MBS8577749-01mLAF635 0.1mL(AF635)
EUR 565

HIBADH (N-term) Rabbit Polyclonal Antibody

E10G31884 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HIBADH siRNA

20-abx919345
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

HIBADH siRNA

20-abx919346
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

HIBADH siRNA

20-abx902458
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

HIBADH (untagged)-Human 3-hydroxyisobutyrate dehydrogenase (HIBADH)

SC100318 10 µg Ask for price

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial)

MBS6006457-02mL 0.2(mL
EUR 695

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial)

MBS6006457-5x02mL 5x0.2mL
EUR 2975

Hibadh (GFP-tagged) - Mouse 3-hydroxyisobutyrate dehydrogenase (Hibadh)

MG204982 10 µg Ask for price

HIBADH (GFP-tagged) - Human 3-hydroxyisobutyrate dehydrogenase (HIBADH)

RG207125 10 µg Ask for price

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (AP)

MBS6306417-02mL 0.2mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (AP)

MBS6306417-5x02mL 5x0.2mL
EUR 4250

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (PE)

MBS6306427-02mL 0.2mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (PE)

MBS6306427-5x02mL 5x0.2mL
EUR 4250

HIBADH (C-term) rabbit polyclonal antibody, Aff - Purified

AP32289PU-N 50 µl Ask for price

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (APC)

MBS6306418-02mL 0.2mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (APC)

MBS6306418-5x02mL 5x0.2mL
EUR 4250

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (FITC)

MBS6306420-02mL 0.2mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (FITC)

MBS6306420-5x02mL 5x0.2mL
EUR 4250

HIBADH siRNA (Rat)

MBS8228228-15nmol 15nmol
EUR 405

HIBADH siRNA (Rat)

MBS8228228-30nmol 30nmol
EUR 565

HIBADH siRNA (Rat)

MBS8228228-5x30nmol 5x30nmol
EUR 2450

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (Biotin)

MBS6306419-02mL 0.2mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (Biotin)

MBS6306419-5x02mL 5x0.2mL
EUR 4250

HIBADH Rabbit pAb

A1264-100ul 100 ul
EUR 369.6

HIBADH Rabbit pAb

A1264-200ul 200 ul
EUR 550.8

HIBADH Rabbit pAb

A1264-20ul 20 ul
EUR 219.6

HIBADH Rabbit pAb

A1264-50ul 50 ul
EUR 267.6

HIBADH Rabbit pAb

E2511167 100ul
EUR 225
Description: Available in various conjugation types.

HIBADH Rabbit pAb

MBS9145167-005mL 0.05mL
EUR 235

HIBADH Rabbit pAb

MBS9145167-5x005mL 5x0.05mL
EUR 885

HIBADH Rabbit pAb

MBS8548411-01mL 0.1mL
EUR 305

HIBADH Rabbit pAb

MBS8548411-01mLAF405L 0.1mL(AF405L)
EUR 565

HIBADH Rabbit pAb

MBS8548411-01mLAF405S 0.1mL(AF405S)
EUR 565

HIBADH Rabbit pAb

MBS8548411-01mLAF610 0.1mL(AF610)
EUR 565

HIBADH Rabbit pAb

MBS8548411-01mLAF635 0.1mL(AF635)
EUR 565

HIBADH Rabbit pAb

A1264 200μL
EUR 88.56

HIBADH Rabbit pAb

A21349 500μL
EUR 88.56

HIBADH siRNA (Human)

MBS8241145-15nmol 15nmol
EUR 405

HIBADH siRNA (Human)

MBS8241145-30nmol 30nmol
EUR 565

HIBADH siRNA (Human)

MBS8241145-5x30nmol 5x30nmol
EUR 2450

HIBADH siRNA (Mouse)

MBS8231388-15nmol 15nmol
EUR 405

HIBADH siRNA (Mouse)

MBS8231388-30nmol 30nmol
EUR 565

HIBADH siRNA (Mouse)

MBS8231388-5x30nmol 5x30nmol
EUR 2450

Hibadh (Myc-DDK-tagged) - Mouse 3-hydroxyisobutyrate dehydrogenase (Hibadh)

MR204982 10 µg Ask for price

HIBADH (Myc-DDK-tagged)-Human 3-hydroxyisobutyrate dehydrogenase (HIBADH)

RC207125 10 µg Ask for price

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 405)

MBS6306422-01mL 0.1mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 405)

MBS6306422-5x01mL 5x0.1mL
EUR 4250

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 490)

MBS6306423-01mL 0.1mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 490)

MBS6306423-5x01mL 5x0.1mL
EUR 4250

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 550)

MBS6306424-01mL 0.1mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 550)

MBS6306424-5x01mL 5x0.1mL
EUR 4250

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 650)

MBS6306425-01mL 0.1mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 650)

MBS6306425-5x01mL 5x0.1mL
EUR 4250

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 750)

MBS6306426-01mL 0.1mL
EUR 980

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (MaxLight 750)

MBS6306426-5x01mL 5x0.1mL
EUR 4250

Hibadh (untagged ORF) - Rat 3-hydroxyisobutyrate dehydrogenase (Hibadh), (10 ug)

RN214073 10 µg Ask for price

HIBADH Blocking Peptide

33R-10017 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HIBADH antibody, catalog no. 70R-2529

HIBADH Blocking Peptide

33R-1292 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ARHGAP28 antibody, catalog no. 70R-3328

HIBADH Blocking Peptide

20-abx162488
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

HIBADH Blocking Peptide

DF12632-BP 1mg
EUR 234

HIBADH Blocking Peptide

MBS8239477-1mg 1mg
EUR 190

HIBADH Blocking Peptide

MBS8239477-5mg 5mg
EUR 345

HIBADH Blocking Peptide

MBS8239477-5x5mg 5x5mg
EUR 1465

HIBADH Blocking Peptide

MBS9621337-1mg 1mg
EUR 380

HIBADH Blocking Peptide

MBS9621337-5x1mg 5x1mg
EUR 1650

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (AP)

MBS6381100-01mL 0.1mL
EUR 920

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (AP)

MBS6381100-5x01mL 5x0.1mL
EUR 3990

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) APC

MBS6381101-01mL 0.1mL
EUR 920

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) APC

MBS6381101-5x01mL 5x0.1mL
EUR 3990

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (HRP)

MBS6381104-01mL 0.1mL
EUR 920

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (HRP)

MBS6381104-5x01mL 5x0.1mL
EUR 3990

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (PE)

MBS6381110-01mL 0.1mL
EUR 920

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (PE)

MBS6381110-5x01mL 5x0.1mL
EUR 3990

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (Biotin)

MBS6381102-01mL 0.1mL
EUR 920

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (Biotin)

MBS6381102-5x01mL 5x0.1mL
EUR 3990

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (FITC)

MBS6381103-01mL 0.1mL
EUR 920

HIBADH (3-hydroxyisobutyrate Dehydrogenase, Mitochondrial, HIBADH, MGC40361, NS5ATP1) (FITC)

MBS6381103-5x01mL 5x0.1mL
EUR 3990

Rat Hibadh ELISA Kit

ELI-35175r 96tests
EUR 756

HIBADH, NT (HIBADH, 3-hydroxyisobutyrate dehydrogenase, mitochondrial) (Azide free) (HRP)

MBS6306421-02mL 0.2mL
EUR 980

Now we have screened, in FRT cells expressing the 3849+10 kb C-to-T splicing mutation, ~30 2′-O-Methyl-modified phosphorothioate ASOs, focused to forestall the popularity and inclusion of a cryptic exon generated because of the mutation. The impact of extremely potent ASO candidates on the splicing sample, protein maturation and CFTR operate was additional analyzed in nicely differentiated main human nasal and bronchial epithelial cells, derived from sufferers carrying at the least one 3849+10 kb C-to-T allele.

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