Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Locked nucleic acid-modified antisense oligonucleotides (ASOs) can obtain strongly totally different levels of goal knockdown regardless of having comparable biophysical properties and 100% homology with their goal. The determinants for this statement stay largely unknown. We used multi-specific ASOs which have 100% sequence complementarity with a typical goal (IDO1) and a special variety of numerous targets and investigated their impact on gene expression in a cell line by RNA-sequencing. We noticed a major larger likelihood for downregulation of lengthy genes in comparison with brief genes, of genes with excessive in comparison with decrease expression, and of genes which have a couple of binding web site for the respective ASO.

By investigating the expression of genes which have binding websites for a couple of ASO we recognized the person binding web site being an vital determinant for exercise. Underneath the chosen experimental circumstances we have now not seen indications that availability of RNase H is a limiting issue because the variety of degraded goal RNA molecules correlated considerably with the variety of predicted goal RNA molecules. Taken collectively, through the use of multi-specific ASOs as software compounds we recognized determinants for ASO exercise that may be considered to enhance the choice technique of extremely potent and selective ASOs sooner or later.

Liver-Focused Supply of Oligonucleotides with N-Acetylgalactosamine Conjugation

The potential therapeutic utility of oligonucleotides (ONs) that selectively suppress goal genes by means of antisense and RNA interference mechanisms has attracted nice consideration. The medical functions of ONs have overcome a number of obstacles and turn into one of the crucial energetic areas for the event of novel therapeutics. To attain environment friendly and particular mobile internalization, conjugation of a wide range of purposeful teams to ONs has been the topic of intensive investigations over the previous decade. Amongst them, a promising liver-targeted N-acetylgalactosamine (GalNAc) ligand has been evaluated in a number of preclinical and medical trials for enhancing the mobile uptake and tissue particular supply of ONs.

GalNAc-based supply depends on the truth that liver hepatocytes abundantly and particularly categorical the asialoglycoprotein receptor that binds and uptakes circulating glycoproteins by way of receptor-mediated endocytosis. Lately, encouraging progress has been made within the discipline of GalNAc conjugates. This assessment goals to supply an summary of GalNAc-mediated liver-targeted supply of small interfering RNA and antisense oligonucleotides, and the immense effort in addition to current advances within the improvement of GalNAc-conjugated brokers are described.

Molecular analysis of viral genotyping devoid of polymerase chain response (PCR) amplification in medical cohorts has hitherto been difficult. Right here we current a simplified molecular diagnostic technique for direct genotyping of hepatitis C virus (HCV) 1 and three (prevalent worldwide) utilizing a mix of rationally designed genotype-specific antisense oligonucleotides (ASOs) and plasmonic gold nanoparticles. The ASOs particular to genotypes 1 and three have been designed from the nonstructural area 5A (NS5A) of the viral genome utilizing the ClustalW a number of sequence alignment software.

A complete of 79 medical samples together with 18 HCV genotype 1, 18 HCV genotype 3, one HIV constructive, one HBV constructive, and 41 wholesome controls have been examined towards each the designed ASOs. The research reveals 100% specificity and sensitivity with the employed samples and thereby opens up new avenues for PCR-free direct genotyping of different viruses as nicely, by means of the rational design of ASOs.

Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

A extremely potent lead ASO, effectively delivered by free uptake, was capable of considerably enhance the extent of accurately spliced mRNA and fully restore the CFTR operate to wild kind ranges in cells from a homozygote affected person. This ASO led to CFTR operate with a median of 43% of untamed kind ranges in cells from varied heterozygote sufferers. Optimized effectivity of the lead ASO was additional obtained with 2′-Methoxy Ethyl modification (2’MOE). The extremely environment friendly splicing modulation and purposeful correction, achieved by free uptake of the chosen lead ASO in varied sufferers, exhibit the ASO therapeutic potential profit for CF sufferers carrying splicing mutations and is aimed to function the premise for our present medical improvement.

PaintSHOP allows the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments

Fluorescence in situ hybridization (FISH) permits researchers to visualise the spatial place and amount of nucleic acids in mounted samples. Not too long ago, appreciable progress has been made in growing oligonucleotide (oligo)-based FISH strategies which have enabled researchers to review the three-dimensional group of the genome at super-resolution and visualize the spatial patterns of gene expression for 1000’s of genes in particular person cells. Nevertheless, there are few present computational instruments to assist the bioinformatics workflows obligatory to hold out these experiments utilizing oligo FISH probes.

Right here, we introduce paint server and homology optimization pipeline (PaintSHOP), an interactive platform for the design of oligo FISH experiments. PaintSHOP allows researchers to establish probes for his or her experimental targets effectively, to include extra obligatory sequences equivalent to primer pairs and to simply generate recordsdata documenting library design. PaintSHOP democratizes and standardizes the method of designing complicated probe units for the oligo FISH neighborhood.

HIBADH Antibody

1-CSB-PA566343
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against HIBADH. Recognizes HIBADH from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

HIBADH Antibody

1-CSB-PA006776
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against HIBADH. Recognizes HIBADH from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

HIBADH Antibody

DF12632 100ul
EUR 280
Description: Human,Mouse,Rat

HIBADH Antibody

E034327 100μg/100μl
EUR 255
Description: Available in various conjugation types.

HIBADH Antibody

E11-14092C 100μg
EUR 225
Description: Available in various conjugation types.

HIBADH Antibody

E91264 100ul
EUR 255
Description: Available in various conjugation types.

HIBADH Antibody

DF12632-100ul 100ul
EUR 280

HIBADH Antibody

DF12632-200ul 200ul
EUR 350

anti- HIBADH antibody

FNab03855 100µg
EUR 658.5
Description: Antibody raised against HIBADH

HIBADH Conjugated Antibody

C34327 100ul
EUR 476.4

HIBADH Polyclonal Antibody

A73425
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

HIBADH Polyclonal Antibody

ABP53601-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of HIBADH from Human, Mouse, Rat. This HIBADH antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human HIBADH at AA rangle: 250-330

HIBADH Polyclonal Antibody

ABP53601-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of HIBADH from Human, Mouse, Rat. This HIBADH antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human HIBADH at AA rangle: 250-330

HIBADH Polyclonal Antibody

ABP53601-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of HIBADH from Human, Mouse, Rat. This HIBADH antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human HIBADH at AA rangle: 250-330

HIBADH Polyclonal Antibody

ES4600-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against HIBADH from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

HIBADH Polyclonal Antibody

ES4600-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against HIBADH from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

HIBADH Polyclonal Antibody

E20-72131 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal HIBADH Antibody (N-term)

APR07742G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIBADH (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal HIBADH Antibody (aa281-330)

APR07741G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIBADH (aa281-330). This antibody is tested and proven to work in the following applications:

Hibadh/ Rat Hibadh ELISA Kit

ELI-35175r 96 Tests
EUR 1063.2

HIBADH

E8ER1910-59 100ul
EUR 275
Description: Available in various conjugation types.

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx233855-100ug 100 ug
EUR 610.8

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx214624
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx121493
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx326435
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx110711
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx014090
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx029841-400ul 400 ul
EUR 627.6

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

abx029841-80l 80 µl
EUR 343.2

3-Hydroxyisobutyrate Dehydrogenase (HIBADH) Antibody

20-abx001170
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

HIBADH siRNA

20-abx919345
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

HIBADH siRNA

20-abx919346
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

HIBADH siRNA

20-abx902458
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

HIBADH Rabbit pAb

A1264-100ul 100 ul
EUR 369.6

HIBADH Rabbit pAb

A1264-200ul 200 ul
EUR 550.8

HIBADH Rabbit pAb

A1264-20ul 20 ul
EUR 219.6

HIBADH Rabbit pAb

A1264-50ul 50 ul
EUR 267.6

HIBADH Rabbit pAb

E2511167 100ul
EUR 225
Description: Available in various conjugation types.

HIBADH Blocking Peptide

33R-10017 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HIBADH antibody, catalog no. 70R-2529

HIBADH Blocking Peptide

33R-1292 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ARHGAP28 antibody, catalog no. 70R-3328

HIBADH Blocking Peptide

DF12632-BP 1mg
EUR 234

HIBADH Blocking Peptide

20-abx162488
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Mouse Hibadh ELISA KIT

ELI-49758m 96 Tests
EUR 1038

HIBADH ELISA KIT|Human

EF004545 96 Tests
EUR 826.8

Human HIBADH ELISA KIT

ELI-24677h 96 Tests
EUR 988.8

Bovine HIBADH ELISA KIT

ELI-35174b 96 Tests
EUR 1113.6

Rat HIBADH shRNA Plasmid

20-abx986119
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human HIBADH shRNA Plasmid

20-abx957600
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse HIBADH shRNA Plasmid

20-abx975120
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Hibadh ORF Vector (Rat) (pORF)

ORF068182 1.0 ug DNA
EUR 607.2

HIBADH (N-term) Rabbit pAb

E2613641 100ul
EUR 225
Description: Available in various conjugation types.

HIBADH Recombinant Protein (Rat)

RP204542 100 ug Ask for price

HIBADH Recombinant Protein (Mouse)

RP141443 100 ug Ask for price

HIBADH Recombinant Protein (Human)

RP062118 100 ug Ask for price

HIBADH ORF Vector (Human) (pORF)

ORF020707 1.0 ug DNA
EUR 486

Hibadh ORF Vector (Mouse) (pORF)

ORF047149 1.0 ug DNA
EUR 607.2

[KO Validated] HIBADH Rabbit pAb

A19871-100ul 100 ul
EUR 492

[KO Validated] HIBADH Rabbit pAb

A19871-200ul 200 ul
EUR 685.2

[KO Validated] HIBADH Rabbit pAb

A19871-20ul 20 ul
EUR 265.2

[KO Validated] HIBADH Rabbit pAb

A19871-50ul 50 ul
EUR 344.4

Hibadh ELISA Kit (Mouse) (OKEH02246)

OKEH02246 96 Wells
EUR 934.8
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.081 ng/mL

HIBADH ELISA Kit (Human) (OKEH05594)

OKEH05594 96 Wells
EUR 794.4
Description: Description of target: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.08 ng/mL

Human HIBADH Protein Lysate 20ug

IHUHIBADHPLLY20UG each
EUR 213
Description: Human HIBADH Protein Lysate 20ug

Hibadh 3'UTR GFP Stable Cell Line

TU255763 1.0 ml Ask for price

Hibadh 3'UTR GFP Stable Cell Line

TU159496 1.0 ml Ask for price

HIBADH 3'UTR GFP Stable Cell Line

TU059771 1.0 ml
EUR 1672.8

Hibadh sgRNA CRISPR Lentivector set (Rat)

K7081501 3 x 1.0 ug
EUR 406.8

HIBADH Protein Vector (Rat) (pPM-C-HA)

PV272728 500 ng
EUR 723.6

HIBADH sgRNA CRISPR Lentivector set (Human)

K0950801 3 x 1.0 ug
EUR 406.8

Hibadh sgRNA CRISPR Lentivector set (Mouse)

K3137901 3 x 1.0 ug
EUR 406.8

HIBADH Protein Vector (Rat) (pPB-C-His)

PV272726 500 ng
EUR 723.6

HIBADH Protein Vector (Rat) (pPB-N-His)

PV272727 500 ng
EUR 723.6

HIBADH Protein Vector (Rat) (pPM-C-His)

PV272729 500 ng
EUR 723.6

HIBADH Protein Vector (Human) (pPM-C-HA)

PV082827 500 ng
EUR 662.4

HIBADH Protein Vector (Mouse) (pPM-C-HA)

PV188596 500 ng
EUR 723.6

HIBADH Protein Vector (Human) (pPB-C-His)

PV082825 500 ng
EUR 662.4

HIBADH Protein Vector (Human) (pPB-N-His)

PV082826 500 ng
EUR 662.4

HIBADH Protein Vector (Human) (pPM-C-His)

PV082828 500 ng
EUR 662.4

HIBADH Protein Vector (Mouse) (pPB-C-His)

PV188594 500 ng
EUR 723.6

HIBADH Protein Vector (Mouse) (pPB-N-His)

PV188595 500 ng
EUR 723.6

HIBADH Protein Vector (Mouse) (pPM-C-His)

PV188597 500 ng
EUR 723.6

HIBADH 3'UTR Luciferase Stable Cell Line

TU009771 1.0 ml
EUR 1672.8

Hibadh 3'UTR Luciferase Stable Cell Line

TU109496 1.0 ml Ask for price

Hibadh 3'UTR Luciferase Stable Cell Line

TU205763 1.0 ml Ask for price

Hibadh sgRNA CRISPR Lentivector (Rat) (Target 1)

K7081502 1.0 ug DNA
EUR 184.8

Hibadh sgRNA CRISPR Lentivector (Rat) (Target 2)

K7081503 1.0 ug DNA
EUR 184.8

Hibadh sgRNA CRISPR Lentivector (Rat) (Target 3)

K7081504 1.0 ug DNA
EUR 184.8

Recombinant 3-Hydroxyisobutyrate Dehydrogenase (HIBADH)

4-RPG362Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human 3-Hydroxyisobutyrate Dehydrogenase expressed in: E.coli

Recombinant 3-Hydroxyisobutyrate Dehydrogenase (HIBADH)

RPU55979-100ug 100ug
EUR 712.8

Recombinant 3-Hydroxyisobutyrate Dehydrogenase (HIBADH)

RPU55979-1mg 1mg
EUR 2808

Recombinant 3-Hydroxyisobutyrate Dehydrogenase (HIBADH)

RPU55979-50ug 50ug
EUR 432

HIBADH sgRNA CRISPR Lentivector (Human) (Target 1)

K0950802 1.0 ug DNA
EUR 184.8

HIBADH sgRNA CRISPR Lentivector (Human) (Target 2)

K0950803 1.0 ug DNA
EUR 184.8

HIBADH sgRNA CRISPR Lentivector (Human) (Target 3)

K0950804 1.0 ug DNA
EUR 184.8

Hibadh sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3137902 1.0 ug DNA
EUR 184.8

Hibadh sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3137903 1.0 ug DNA
EUR 184.8

Hibadh sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3137904 1.0 ug DNA
EUR 184.8

HIBADH Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV682483 1.0 ug DNA
EUR 818.4

HIBADH Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV682487 1.0 ug DNA
EUR 818.4

HIBADH Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV682488 1.0 ug DNA
EUR 818.4

Rat 3-Hydroxyisobutyrate Dehydrogenase (HIBADH) ELISA Kit

abx516058-96tests 96 tests
EUR 886.8

Mouse 3-Hydroxyisobutyrate Dehydrogenase (HIBADH) ELISA Kit

abx254908-96tests 96 tests
EUR 886.8

Human 3-Hydroxyisobutyrate Dehydrogenase (HIBADH) ELISA Kit

abx516056-96tests 96 tests
EUR 801.6

Rabbit 3- hydroxyisobutyrate dehydrogenase, HIBADH ELISA KIT

ELI-35047Ra 96 Tests
EUR 1113.6

Human 3-Hydroxyisobutyrate Dehydrogenase(HIBADH)ELISA Kit

QY-E05213 96T
EUR 433.2

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K7081505 3 x 1.0 ug
EUR 451.2

HIBADH sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0950805 3 x 1.0 ug
EUR 451.2

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3137905 3 x 1.0 ug
EUR 451.2

Pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E07H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E07H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E07H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E08H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E08H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E08H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E02H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E02H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E02H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E06H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E06H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E06H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E04H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E04H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E04H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E03H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E03H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E03H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E01H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E01H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E01H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E09H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E09H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E09H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K7081506 1.0 ug DNA
EUR 200.4

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K7081507 1.0 ug DNA
EUR 200.4

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K7081508 1.0 ug DNA
EUR 200.4

Mouse Hibadh/ 3-hydroxyisobutyrate dehydrogenase, mitochondrial ELISA Kit

E0670Mo 1 Kit
EUR 758.4

Mouse Hibadh(3-hydroxyisobutyrate dehydrogenase, mitochondrial) ELISA Kit

EM0557 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Human HIBADH/ 3-hydroxyisobutyrate dehydrogenase, mitochondrial ELISA Kit

E1120Hu 1 Kit
EUR 726

Human 3-hydroxyisobutyrate dehydrogenase, mitochondrial,HIBADH ELISA kit

YLA2069HU-48T 48T
EUR 435

Human 3-hydroxyisobutyrate dehydrogenase, mitochondrial,HIBADH ELISA kit

YLA2069HU-96T 96T
EUR 562.5

Human 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) ELISA Kit

RK10159 96T
EUR 280

Mouse 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) ELISA Kit

RK12564 96T
EUR 280

HIBADH sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0950806 1.0 ug DNA
EUR 200.4

HIBADH sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0950807 1.0 ug DNA
EUR 200.4

HIBADH sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0950808 1.0 ug DNA
EUR 200.4

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3137906 1.0 ug DNA
EUR 200.4

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3137907 1.0 ug DNA
EUR 200.4

Hibadh sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3137908 1.0 ug DNA
EUR 200.4

HIBADH Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV682484 1.0 ug DNA
EUR 818.4

HIBADH Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV682485 1.0 ug DNA
EUR 888

HIBADH Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV682486 1.0 ug DNA
EUR 888

Guinea pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E05H1386-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E05H1386-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) ELISA kit

E05H1386-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig 3 hydroxyisobutye dehydrogenase, mitochondrial(HIBADH) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Anti HIBADH Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence)

IRBAMLHIBADHAP289120UL each
EUR 346
Description: Rabbit Anti HIBADH Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence)

Rabbit Anti HIBADH Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence)

IRBAMLHIBADHAP289200UL each
EUR 509
Description: Rabbit Anti HIBADH Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot,Immunofluorescence)

Anti-HIBADH Antibody

A08760-1 100ul
EUR 476.4
Description: Rabbit Polyclonal HIBADH Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-HIBADH antibody

PAab03855 100 ug
EUR 463.2

Anti-HIBADH antibody

STJ93496 200 µl
EUR 236.4
Description: Rabbit polyclonal to HIBADH.

Anti-HIBADH antibody

STJ11100747 100 µl
EUR 495.6
Description: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

Anti-HIBADH antibody

STJ23942 100 µl
EUR 332.4
Description: This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

Rabbit anti-HIBADH Antibody

YLD3805-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to HIBADH

Rabbit anti-HIBADH Antibody

YLD3805-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to HIBADH

Rabbit anti-HIBADH Antibody

DL92995A-100ul 100 ul
EUR 325
Description: 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH

Rabbit anti-HIBADH Antibody

DL92995A-50ul 50 ul
EUR 227.5
Description: 3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH

anti-HIBADH

YF-PA17437 50 ug
EUR 435.6
Description: Mouse polyclonal to HIBADH

anti-HIBADH

YF-PA17438 100 ug
EUR 483.6
Description: Rabbit polyclonal to HIBADH

PE Anti-human CD22 Antibody *HIB22*

102201L0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD22 Antibody *HIB22*

102201L1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD22 Antibody *HIB22*

102201L2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD19 Antibody *HIB19*

101921L0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD19 Antibody *HIB19*

101921L1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD19 Antibody *HIB19*

101921L2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD19 Antibody *HIB19*

101921L0-25tests 25 tests
EUR 179
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

PE Anti-human CD19 Antibody *HIB19*

101921L1-100tests 100 tests
EUR 505
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

PE Anti-human CD19 Antibody *HIB19*

101921L2-500tests 500 tests
EUR 1887
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

PE Anti-human CD22 Antibody *HIB22*

102201L0-25tests 25 tests
EUR 179
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

PE Anti-human CD22 Antibody *HIB22*

102201L1-100tests 100 tests
EUR 505
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

PE Anti-human CD22 Antibody *HIB22*

102201L2-500tests 500 tests
EUR 1887
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

APC Anti-human CD22 Antibody *HIB22*

102201C0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD22 Antibody *HIB22*

102201C1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD22 Antibody *HIB22*

102201C2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD19 Antibody *HIB19*

101921C0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD19 Antibody *HIB19*

101921C1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD19 Antibody *HIB19*

101921C2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD19 Antibody *HIB19*

101921C0-25tests 25 tests
EUR 179
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

APC Anti-human CD19 Antibody *HIB19*

101921C1-100tests 100 tests
EUR 505
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

APC Anti-human CD19 Antibody *HIB19*

101921C2-500tests 500 tests
EUR 1887
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

APC Anti-human CD22 Antibody *HIB22*

102201C0-25tests 25 tests
EUR 179
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

APC Anti-human CD22 Antibody *HIB22*

102201C1-100tests 100 tests
EUR 505
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

APC Anti-human CD22 Antibody *HIB22*

102201C2-500tests 500 tests
EUR 1887
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

FITC Anti-human CD22 Antibody *HIB22*

102201H0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD22 Antibody *HIB22*

102201H1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD19 Antibody *HIB19*

101921H0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD19 Antibody *HIB19*

101921H1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD19 Antibody *HIB19*

101921H0-100tests 100 tests
EUR 245
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

FITC Anti-human CD19 Antibody *HIB19*

101921H1-500tests 500 tests
EUR 918
Description: HIB19 is an anti-human monoclonal antibody that recognizes the CD19 antigen.

FITC Anti-human CD22 Antibody *HIB22*

102201H0-100tests 100 tests
EUR 245
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

FITC Anti-human CD22 Antibody *HIB22*

102201H1-500tests 500 tests
EUR 918
Description: HIB22 is an anti-human monoclonal antibody that recognizes the CD22 antigen.

TRITC Anti-human CD22 Antibody *HIB22*

102201I0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

Now we have screened, in FRT cells expressing the 3849+10 kb C-to-T splicing mutation, ~30 2′-O-Methyl-modified phosphorothioate ASOs, focused to forestall the popularity and inclusion of a cryptic exon generated because of the mutation. The impact of extremely potent ASO candidates on the splicing sample, protein maturation and CFTR operate was additional analyzed in nicely differentiated main human nasal and bronchial epithelial cells, derived from sufferers carrying at the least one 3849+10 kb C-to-T allele.

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