Investigation of the Activity of Antisense Oligonucleotides Targeting Multiple Genes by RNA-Sequencing

Investigation of the Activity of Antisense Oligonucleotides Targeting…

Locked nucleic acid-modified antisense oligonucleotides (ASOs) can obtain strongly totally different levels of goal knockdown regardless of having comparable biophysical properties and 100% homology with their goal. The determinants for this statement stay largely unknown.…
Single Copy Oligonucleotide Fluorescence In Situ Hybridization Probe Design Platforms: Development, Application and Evaluation

Single Copy Oligonucleotide Fluorescence In Situ Hybridization Probe…

Oligonucleotides fluorescence in situ hybridization (Oligo-FISH) is an rising know-how and is a crucial device in analysis areas comparable to detection of chromosome variation, identification of allopolyploid, and deciphering of three-dimensional (3D) genome constructions. Primarily…